Working in yeast and human pluripotent stem cells (hPSCs), we shall establish whether modulating acetyl-CoA between acetylation and metabolism is a convergent mechanism to improve ageing health.
Metabolite cofactors for epigenetic modifying enzymes are highly conserved, making yeast an attractive system to dissect the impact of metabolites on epigenetic change during ageing. We have shown that metabolic alterations can alter the ageing trajectory of yeast cells: changing diet without caloric restriction or forcing an increase in respiration suppressed many phenotypes of ageing.
Mauris accumsan ligula iaculis, facilisis nisi et, tempor purus. Pellentesque dui risus, eleifend sed lobortis id, sagittis eget libero.